Associate Professor Shaun Sandow

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Associate Professor Shaun Sandow


Teaching areas

  • Cardiovascular and Respiratory Physiology

Research areas

  • cardiovascular
  • control of vascular tone
  • endothelial and smooth muscle cell biology
  • cell coupling, gap junctions and connexins
  • remodelling in development (pregnancy and growth) and disease, including obesity, diabetes, stroke
  • microdomain signaling


Working with colleagues in Australia, Canada, Britain and Denmark, our studies aim to determine some of the ways that cells in arteries communicate with one another and specifically, at how cells control the balance between the way that arteries narrow (constrict) and enlarge (dilate). This balance is referred to as vascular tone and is the main determinant of blood pressure and thus cardiovascular disease. Coordination of vascular tone is dependent on signals passing through junctions within and between the cellular layers in arteries. Our studies correlate anatomy, function, molecular and biochemical data, to identify the fundamental pathways that underlie blood vessel function and thereby determine targets for the correction of vascular disease.

Professional memberships

  • American Society for Pharmacology and Experimental Therapeutics (2010-present)
  • Australian and New Zealand Microcirculation Society (2001-present)
  • Australian Physiological Society (1995-present)
  • Australian Vascular Biology Society (2012-present)
  • Microcirculatory Society (US; 2011-present)

Potential research projects for HDR and Honours students

  • Role of endothelial large conductance calcium activated potassium channels in cerebrovascular health and disease (with Tim Murphy and Nicole Jones, University of New South Wales)
  • Identifying targets to correct abnormal blood flow in pregnancy (with Tim Murphy, University of New South Wales; and Leo Leader, Royal Hospital for Women, Sydney)
  • Omega-3 fatty acid supplementation for treatment of abdominal aortic aneurysm — login required (with Fraser Russell, USC) 
  • Cardiovascular mechanisms that underlie the pain and aura phases of migraine (with Vladimir Matchkov, Denmark).

Research grants

Project nameInvestigator(s)Funding bodyYear(s)Funding amount
Identifying treatment targets to improve cerebral blood flow after stroke and hypoxia Dr Shaun Sandow; Dr Tim Murphy; Dr Nicole Jones; Dr Fraser Russell; Dr Rohan Grimley; Dr Andrew Dettrick; Brain Foundation 2016 $34,000
Diabetes Australia Research Trust Millennium Grant Dr Tim Murphy; Dr Shaun Sandow Diabetes Australia 2016-2017 $49,950
GNT1048885 ATP
release from gastrointestinal epithelium: A potential target for the treatment
of slow transient constipation 
Dr Lu Liu; Associate Professor Paul Bertrand; Dr Shaun Sandow National Health and Medical Research Council 2013-2015 $306,806.18
GNT546087 Local mechanisms that determine regional differences in ability of small arteries to deliver blood to organs in diabetes

Associate Professor Helena C Parkington; Dr Shaun L Sandow; Prof Michael Permezel

National Health and Medical Research Council 2009-2012 $735,200
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